?? ???? ????????? ?? ???? ?? ???????? ???????? ?????? ??? ?????? ??? ??? ?? ???? ???? ????????? ?? ???? ????? ?????? ?????? ????? ????? ???? ????? ?? ????? ??? ????? ?????? ????? ????.To cut back the chance of respiratory depression, correct dosing and titration of OPANA ER are crucial [see DOSAGE AND ADMINISTRATION]. Overestimating the OPANA ER do